Fence House / mode:lina architekci

first_img 2016 Photographs Architects: mode:lina architekci Area Area of this architecture project Fence House / mode:lina architekci “COPY” ArchDaily ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/799000/fence-house-mode-lina-architekci Clipboard ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/799000/fence-house-mode-lina-architekci Clipboard Fence House / mode:lina architekciSave this projectSaveFence House / mode:lina architekci CopyHouses•Borówiec, Poland Housescenter_img Area:  290 m² Year Completion year of this architecture project “COPY” Projects Year:  Photographs:  Marcin Ratajczak Manufacturers Brands with products used in this architecture project Manufacturers: Q-railing, BRUGMANArchitect In Charge:Paweł Garus, Jerzy Woźniak, Kinga KinCity:BorówiecCountry:PolandMore SpecsLess SpecsSave this picture!© Marcin Ratajczak In Borówiec near Poznań, once again a house designed by mode:lina™ studio was built. Form of this house: two blocks with a sloping roof and an asymmetric garage cube, is a contemporary interpretation of the traditional style. It is complemented with simple, raw materials: bricks, concrete and sheet in shades of gray.Save this picture!Floor PlanThe street facade has the least windows, protecting the inhabitants from the noise and gives them peace. In addition, various kinds of fences give them the sense of security. That’s where the house got the name from: the Fence House.The shape of this building was dictated by its function. Household members, parents and two children, wanted to live independently. Hence the idea of dividing it into two parts. Separate area on the first floor allows adults to enjoy tranquility while kids can go crazy in their “own house”.Save this picture!© Marcin RatajczakGround floor is a common part for all inhabitants. There’s the unique kitchen extended into the garden and a large living room with mezzanine, reaching the attic. An unusual feature is the window in the hallway, which exhibits the owner’s unique car inside a graphite garage cube.Save this picture!© Marcin RatajczakWindow openings allow you to look inside from one zone to the another. Huge glazing connects the kitchen and the dining area with the garden and the surrounding forest.Save this picture!© Marcin RatajczakThe living room is a large, open space, where the irregular window theme appears, exposing the natural exterior. The most interesting part of the room is a mezzanine with library, based on the large steel beams. Bookshelves were built with old oak beams, one of Poznan’s old townhouse.Save this picture!© Marcin RatajczakBy chance, the chosen parcel is adjacent to the already existing House On The Rocks.Save this picture!© Marcin RatajczakProject gallerySee allShow lessSporthalle Kepler- und Humboldt-Gymnasium / h4a ArchitektenSelected ProjectsHasshoden-Charnel House in Ryusenji Temple / Love ArchitectureSelected Projects Share Poland Save this picture!© Marcin Ratajczak Share CopyAbout this officemode:lina architekciOfficeFollowProductConcrete#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousesBorówiecPolandPublished on November 15, 2016Cite: “Fence House / mode:lina architekci” 15 Nov 2016. ArchDaily. Accessed 11 Jun 2021. ISSN 0719-8884Browse the CatalogPanels / Prefabricated AssembliesTechnowoodGRP Siding Façade SystemPlasticsMitrexSolar SidingMetal PanelsAurubisCopper Alloy: Nordic RoyalSystems / Prefabricated PanelsKalwall®Translucent WalkwaysPanels / Prefabricated AssembliesIsland Exterior FabricatorsSpecialty Facade SystemsLightsLouis PoulsenLamps – LP Slim BoxWoodBruagAcoustic Panels with LEDTiles / Mosaic / GresiteHisbalitMosaic Tiles – Palm SpringsMineral / Organic PaintsKEIMBlack Concrete – Concretal®-BlackSuspension SystemsMetawellAluminum Panels for Smart CeilingsDoorsGorter HatchesFloor Door – Fire RatedBricksDEPPEWaterstruck Bricks – 1622/1635ekws DFMore products »Save想阅读文章的中文版本吗?栅栏式住宅 / mode:lina architekci是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my streamlast_img read more

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UK Radio Aid raises £3,012,345

first_img  32 total views,  1 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis Howard Lake | 20 January 2005 | News UK Radio Aid raises £3,012,345 AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis About Howard Lake Howard Lake is a digital fundraising entrepreneur. Publisher of UK Fundraising, the world’s first web resource for professional fundraisers, since 1994. Trainer and consultant in digital fundraising. Founder of Fundraising Camp and co-founder of GoodJobs.org.uk. Researching massive growth in giving. Tagged with: Digital Events Recruitment / people UK Radio Aid, the unprecedented collaboration between the UK’s commercial radio stations to run a joint fundraising broadcast, has raised over £3 million for the DEC’s tsunami appeal.More than 250 local and national commercial radio stations abandoned their planned schedules for 12 hours on 17 January 2005 to make way for a joint fundraising broadcast.Presenters included Chris Evans, Simon Bates, Kate Thornton, Davina McCall, Zoe Ball, Frank Skinner, Mark Goodier, and Johnny Vaughan. Advertisementlast_img read more

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Barnardo’s seeks volunteers for street collections outside Tesco stores

first_img Howard Lake | 22 July 2006 | News Barnardo’s seeks volunteers for street collections outside Tesco stores Tagged with: Community fundraising Recruitment / people AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis Andrew Nebel, UK Director of Communications at Barnardo’s said; ‘This is the biggest volunteer request we have undertaken recently and we are reliant on the generosity of the UK public to make this a success. Actress Lynda Bellingham is helping the charity promote the campaign.center_img  21 total views,  2 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis Children’s charity Barnardo’s is hoping to recruit 14,000 volunteers to take part in a public collection outside Tesco stores, with the aim of raising £250,000.The charity is asking volunteers, as well as staff and service users over 16, to commit two hours of their time to collect outside their local Tesco store on Friday 29 or Saturday 30 September 2006.Collections will take place in around 738 UK Tesco stores, excluding petrol stations and Express stores. Advertisement About Howard Lake Howard Lake is a digital fundraising entrepreneur. Publisher of UK Fundraising, the world’s first web resource for professional fundraisers, since 1994. Trainer and consultant in digital fundraising. Founder of Fundraising Camp and co-founder of GoodJobs.org.uk. Researching massive growth in giving.last_img read more

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Road Runner Rallies announces ‘Riviera Run’ charity banger rally

first_img What do the Ferrari Museum, Champagne and the Gotthard Pass all have in common? No not James Bond – it’s the Road Runner Rally – the ultimate banger rally experience.Last year, the owner of a Shropshire care company who took part in a charity banger rally, decided he enjoyed it so much he would establish his own unique and ultimate adventure rally – with none of the pitfalls he experienced.Ian Barnes from Shrewsbury, owner and director of Bluebird Care, developed ‘Road Runner Rallies’, with the first charity rally set to take place this year from September 8-13.A banger rally sees participants driving a car worth less than £500, in a journey over several days, having a laugh and taking part in events and challenges – all while raising money for charity.Teams are actively encouraged to dress up, decorate their cars and invent a wacky team name. But it is NOT a race and you can take part at your own enjoyment and leisure and join in as much or as little as you like, though there will be a party each night.In order for Ian to establish the route and all of the tantalizing activities to make the trip one to remember, he avoided everything he didn’t enjoy from his ‘virgin voyage’ and put hours into the research.This January, he and his son Chris went on a recce in order to create the ‘ultimate rally’. They researched the best driving roads, places to stay and things to do along the five day, 1500 mile route across Europe.‘The Riviera Run’ was born and it will see participants starting in France near the ferry port of Calais, travelling through the Swiss Alps, past the Italian lakes and then onto the final leg to Cannes and the French Riviera.Ian and Chris are taking part along with Shrewsbury friends Colin Jones and Dan Wright, as team ‘The Management’. They will be raising funds for The Mouth Cancer Foundation. (www.mouthcancerfoundation.org)Ian said: “I took part in a rally last year because I thought it seemed like fun and would be an adventure for fourblokes. But I thought ‘I could organise a better one. “So I set my mind to it, and my son Chris, who also works for Bluebird Care, has helped me.“A rally suits anyone over 18, male and female. You make friends, help each other out, and get to see so many places and try different things than on a normal holiday. And it costs far less than people might think. Charity-wise, people really get behind it and into the spirit of things dressing up and raising and donating money.”With Road Runner Rallies, the driving times are kept short so you don’t spend too much time on the road – about four hours a day. There is some motorway driving, but driving roads that enable you to see the sights have deliberately been included. All the accommodation, events and optional excursions have been pre-arranged along the way.“We start in France with a welcome party and during the next two days, adventurers can take part in a range of activities, including Champagne tasting, go-karting and a theme park in the snow,” said Ian.“Then it’s onto Switzerland where we will camp by Lake Lucerne and have a barbecue. There is spectacular scenery as we cross the Alps via the Gotthard Pass – which is very James Bond. Then it’s on into Italy and past Lake Como and Lake Maggiore and from there the finish line awaits in the sun on the French Rivera.“A visit to the Ferrari museum awaits for those who are really into their cars – and there’s always shopping and the beach. We end with a huge Paella Party in San Rafael.”The trip is timed from Saturday to Thursday so participants can get home if they want or enjoy a few more days in Europe at their leisure – The Management will be heading to the oldest jazz club in Paris, for example.Overall, Road Runner Rallies is hoping to raise £30,000 for charity through the Riviera Run – it’s up to individual teams what they want to raise for.All cars must be roadworthy and Road Runner Rallies can arrange European breakdown cover for participants. Someone from each team must be sober each morning to drive. Apart from the essentials, Ian and Chris are creating challenges along the way to spice things up and there will be a prize for the best themed car. Two entrants from the local area will be coming as Sergeant Pepper’s Lonely Hearts Club Band. Plus, everyone gets a Road Runner Rally T-shirt and stickers to add to camaraderie.“We will be there to greet people, give you a full guide of the route with details of things to do route including maps and directions for the night’s destination. It’s up to you how you get there! All you have to worry about is burning some rubber! What could possibly go wrong!?” said Ian.The trip costs just £99 to enter and campsites are £9 with an upgrade to a log cabin or a mobile home from as little as £12.50 for a team of four.If you want to take part in the next Road Runner Rally, or get more information call Ian on 07703 686841, email [email protected] or visitwww.road-runner-rallies.co.ukFor more information, contact Catherine Roche or Andy Rao on 01743 454959 | Email [email protected] or [email protected]| Road Runner Rallies announces ‘Riviera Run’ charity banger rally Tagged with: Events Howard Lake | 18 June 2012 | News  37 total views,  1 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis About Howard Lake Howard Lake is a digital fundraising entrepreneur. Publisher of UK Fundraising, the world’s first web resource for professional fundraisers, since 1994. Trainer and consultant in digital fundraising. Founder of Fundraising Camp and co-founder of GoodJobs.org.uk. Researching massive growth in giving. AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThislast_img read more

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Actresses Felicity Huffman and Lori Loughlin face judge in massive ‘Varsity Blues’ college entrance scam

first_imgYinYang/iStock(BOSTON) — Hollywood actresses Felicity Huffman and Lori Loughlin made their first formal appearances Wednesday in Boston federal court along with ten other parents charged in the massive college entrance scandal in which prosecutors say they allegedly lied and bribed to get their children into elite schools across the country.While there was no red carpet, there were plenty of paparazzi photographers, news cameras and even fans there to greet them as they made their way in and out of U.S. District Court.In a camel-colored pantsuit, grey shirt and dark-rimmed eyeglasses, Loughlin, 54, smiled and waved at a group of fans as she and her husband, fashion designer Mossimo Giannulli, dressed in a dark suit and green tie, got out of a black van in front of the courthouse with their team of lawyers.“Hi guys,” Loughlin said to a group of fans, who yelled back, “We love you!”As she entered the courtroom, Loughlin shook hands with prosecutors before she and her husband, who is also charged in the case, took seats in front of Magistrate Judge M. Page Kelley.When her case was called, Loughlin and Giannulli listened as the charges of conspiracy to commit mail fraud and honest services mail fraud were formerly read against them.When asked by Kelley, if she understood the charges, Loughlin affirmed, “Yes, your honor.” Loughlin and Giannulli left the court without entering pleas. They did not speak to reporters.Huffman, 56, wore a black pantsuit and emerald blouse as she sat in court with her brother. She also answered, “Yes, your honor,” when asked if she understood her rights and the charges of conspiracy to commit mail fraud and honest services mail fraud.Her husband, actor William H. Macy, who has not been charged in the federal probe, did not attend the hearing.Huffman and Loughlin are the highest profile defendants indicted in the investigation dubbed by the feds as “Operation Varsity Blues.”They are among 35 parents charged in the scam allegedly masterminded by William Singer, owner of a college counseling service and a sham charity called Key Worldwide Foundation. Singer allegedly accepted bribes totaling $25 million from parents between 2011 and 2018 “to guarantee their children’s admission to elite schools,” including Yale University, the University of Southern California, UCLA, Georgetown, Stanford, the University of Texas, Wake Forest and the University of San Diego, federal prosecutors said.Singer of Newport Beach, California, pleaded guilty in a Boston federal court last month to charges of racketeering conspiracy, money laundering conspiracy, conspiracy to defraud the United States and obstruction of justice.Loughlin and Giannulli “agreed to pay bribes totaling $500,000 in exchange for having their two daughters designated as recruits to the USC crew team — despite the fact that they did not participate in crew — thereby facilitating their admission to USC,” according to the indictment unsealed on March 13. The couple allegedly submitted fake athletic profiles, including “action” photos of their daughters on rowing machines, the indictment alleges.They allegedly paid $50,000 to USC’s associate athletic director, Donna Heinel, to get her to “recruit” their oldest daughter Isabella as a coxswain. After Isabella was accepted, Giannulli allegedly wired another $200,000 to Singer’s bogus charity, the indictment alleges.Heinel pleaded not guilty to racketeering conspiracy last month and her attorney said she is looking forward to “reviewing the government’s evidence and fully restoring Donna’s reputation in the college athletic community.”Loughlin and Giannulli allegedly followed the same scheme for their youngest daughter, according to the indictment. That daughter goes by the name Olivia Jade, and was a social media influencer who before the scandal erupted had endorsement deals from companies like Sephora.Huffman — famous for her Academy Award-nominated role in “Transamerica” and for playing one of the main characters in the television show “Desperate Housewives” — allegedly gave $15,000 to Singer’s bogus charity “to participate in the college entrance exam cheating scheme on behalf of their oldest daughter,” court documents allege.“Huffman later made arrangements to pursue the scheme a second time, for her younger daughter, before deciding not to do so,” court documents allege.Also appearing in Boston federal court Wednesday was Gordon Caplan, who was put on leave from his job as co-chairman of the international law firm Willkie Farr & Gallagher when he was charged. He’s accused of paying $75,000 to rig his daughter’s ACT college entrance exam despite allegedly saying on a recorded phone call he “worried about the moral issue,” according to court documents.Manuel Henriquez, 55, who stepped down as CEO of a Northern California hedge fund, also appeared in court with his wife, Elizabeth, 56. The couple allegedly paid Singer to help their two daughters cheat on their standardized tests, according to the indictment.The couple also allegedly paid $400,000 to Singer’s charity to bribe Georgetown’s tennis coach Gordon Ernst to designate their older daughter as a tennis recruit. Ernst, 52, who is accused of accepting $2.7 million in bribes to designate at least 12 applicants as recruits to Georgetown, has pleaded not guilty.Also appearing in court were the latest parents to be charged in the case, Dr. Gregory Colburn and his wife, Amy. The Colburns both waived a formal reading of the indictment and pleaded not guilty to counts of mail and wire fraud, and conspiracy to commit money laundering. Amy Colburn stood with her hands clasped in front of her during the arraignment.The Colburns allegedly participated in the alleged college entrance cheating scheme on behalf of their son. The couple allegedly transferred stock worth $24,443.50 to Singer’s charity and wrote a check for $547.45, according to the indictment. In addition to the wire fraud charges facing the other parents, the Colburns were indicted on money laundering charges last week.The Colburns’ attorneys released a statement to ABC News saying, “The Colburns are innocent of these charges, and they completely deny the allegations in the indictment.”Bruce Isackson, 61, president of a real estate development firm in California, and his wife, Davina, 55; and Toby MacFarlane, 56, a former senior executive at a title insurance company, also appeared in court.Court documents allege that the Isacksons transferred 2,150 shares of Facebook stock — with a value of about $251,249 at the time — to Singer’s bogus charity in an effort to get their daughter into college as a soccer recruit using falsified athletic profiles, according to court documents.Court documents allege that McFarlane paid thousands to get his daughter into USC as a soccer recruit and, later, gave $200,000 to Singer’s charity to get his son in as a basketball recruit. His daughter graduated from USC in 2018, but “did not play soccer at USC”, according to court documents. His son attended USC briefly but dropped out without ever playing basketball.Homayoun Zadeh, 57, a professor of dentistry at USC, also appeared in court. Zadeh is accused in court documents of having conspired to bribe Heinel, the former USC senior associate athletic director, “to designate his daughter as a lacrosse recruit — despite the fact that she did not play lacrosse competitively — thereby facilitating her admission to USC,” court documents allege.Indicted parents Jane Buckingham, Peter Jan “P.J.” Sartorio and John B. Wilson were initially scheduled to be in court on Wednesday, but their hearings were postponed until later this month.Sartorio’s lawyer filed a motion to delay his hearing on grounds “that he intends to plead guilty.”Sartorio, 53, of California, founder and CEO of a natural and organic food company, allegedly paid Singer $15,000 in cash in or about June 2017 to have somoene “correct” the answers to his daughter’s ACT entrance exam, according to court records.Copyright © 2019, ABC Radio. All rights reserved.last_img read more

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Fire crew visit fellow firefighter in the hospital using fire truck ladder

first_imgCourtesy Miami-Dade Fire Rescue(MIAMI) — After one of their own fell sick, the Miami-Dade Fire Rescue squad found a way to safely pay a visit to their coworker at the hospital.Kenneth Wood, the battalion chief of Miami-Dade Fire Rescue 13, helped organize the visit to the unnamed firefighter, who has been hospitalized three times since March 19 due to complications with the coronavirus, according to Wood.“The lieutenant [in the hospital] is one of mine that I’m responsible for,” said Wood, who added a few other members of his crew are also sick with coronavirus-like symptoms. “I set up a text group so that we could see how everybody’s feeling during the day and to keep the [camaraderie] going throughout the whole process. We mess around with each other, to keep things light.”Together, with the help of Miami-Dade Fire Rescue Station 37, Station 36, Station 13 and the hospital, Wood said the fire squad used the fire truck ladder to visit the lieutenant on the fourth floor of the Florida hospital, that’s left unnamed for privacy, on April 3, 2020.“You can’t really go visit [the sick firefighters], you’re not allowed to go visit them … [We visited] this lieutenant because he’s been the most sick,” said Wood. “I made the appropriate phone calls and we set it in place and set the time and then went out and did it.”Firefighters from each station were able to take turns using the fire truck ladder to visit the sick lieutenant at his hospital window. Emotions were high, Wood said, and everybody could hear how excited and touched the lieutenant was during the visit.“I think that [visiting him] really put things in perspective for everybody just how serious this whole thing is. He was short of breath the entire conversation and it was chilling the emotion in his voice,” said Wood, who has been colleagues with this lieutenant for about 16 years. “[He’s] been cooped up there with stress and he’s been isolated.”Wood said the visit was a welcome break for the crew since most of their recent calls have been coronavirus-related and the crisis has taken a toll.“Everything’s just been so negative lately,” said Wood. “So I think it was nice to finally have a good feeling, opposed to all the bad stuff that’s been happening.”Copyright © 2020, ABC Audio. All rights reserved.last_img read more

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Ballin’ for a tenner

first_imgHarris Manchester are running an Oxford ball with tickets set to cost only £10 on Friday of 7th week.The ball will have three different parts. First, a pre-dinner party will feature a retro mini-golf stall, a retro strong man ‘ring the bell’ stall and a candy floss stall. These will be accompanied by Prosecco and Pimms and a performance from Dots Funk Odyssey. The capacity for this section is over 150 people.A four course formal dinner will be held for 150 guests with musical entertainment throughout. Finally, the after party will continue in another venue, the 1855 Wine Bar in the Castle Quarter with capacity of 100. The separate after party venue has been chosen to accommodate finalists preparing for exams in college.The event is being funded by both the MCR and JCR. Harris Manchester College has also agreed to subsidise the cost of the ball by £1000, despite having the smallest fi nancial endowment of any Oxford college, which as of 2012 was at £6 million.Charlotte Baker, a member of the Harris Manchester Ball Committee said, “The college is subsidising so much because we feel that more things in Oxford, especially classic Oxford events like balls, need to be more accessible to all and as the smallest college in Oxford it is important that we are as inclusive as possible.“One of the most exciting and special things about Harris Manchester is the huge overlap in the JCR and MCR, mainly because of the lack of difference in ages. This gives Harris Manchester the maturity of an MCR but the vibrant lust for life of a JCR!“Although previously the two have been officially quite separate, the current committee and college community as a whole felt inspired to combine all college efforts to create a super-massive event (in Harris Manchester terms!) that will hopefully become the beginning of a tradition for years to come.“The current sense of anticipation and excitement within the college hints it’s going to be a colght to remember!”Tickets for Oxford Balls are typically very expensive, usually costing over £100. A non-dining ticket for the White Tie New College Commemoration ball, which is to be held on the 25th June, costs £185.One DPhil student at Harris Manchester told Cherwell, “I went to a ball this year and another last year and was kind of overpriced for what they ended up being and was kind of disappointed. So at least with £10 there won’t be disappointment amongst the students.”last_img read more

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Irwin’s reaches agreement with union over pay

first_imgPortadown-based Irwin’s Bakery has come to an agreement with workers over rates of pay.Employees will receive a 2.4% increase across all rates of pay as well as an additional day’s holiday to be taken before 31 July 2019. Back pay will be payable from 1 August 2018.Previously, members of the Bakers Food and Allied Workers Union (BFAWU) had voted to take industrial action over rates of pay and changes to the company’s sick pay scheme.Following further discussions, the strike was postponed on 26 September to allow the union to ballot workers on the updated offer. The industrial action will no longer take place.“Following a recent suspension of planned Industrial action in the form of strike action with our members in Irwin’s Bakery, we have successfully reached a resolution to the 2018-2019 pay dispute and will no longer be progressing to industrial action,” said Laura Graham, Northern Ireland regional officer for BFAWU.“We would like to thank all of our members at this site for the support they have given the union and also thank the union representatives for their hard work during this time.”last_img read more

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Nirvana ‘In Utero’ Producer Steve Albini Wins World Series Of Poker Tournament

first_imgThis past weekend, multi-instrumentalist and decorated record producer Steve Albini showed off one of his other, unrelated talents in a big way, winning the World Series of Poker‘s $1,500 Seven Card Stud tournament, one of many events hosted by the World Series of Poker (WSOP) each year. Albini bested 309 other players in the high-profile tournament, taking home the nearly-$106,000 prize in addition to his first WSOP gold bracelet, the most coveted prize in the world of professional poker.As Albini told the WSOP after his win:I am ecstatic that a player as mediocre as me can outlast all of these better players and end up with a bracelet. There’s still hope for everybody! … This year the stud event occurred simultaneously with the Seniors Event, and simultaneously with the $50K [Poker Players Championship, both of which included many talented seven-card stud players]. So the field for the stud tournament, I think, was kind of historically weak, which allowed a sucker like me to make it to the final table. With some prescient coaching from my friends and a good run of cards – I ran pretty fucking good as well. I hit a lot of hands early in the final table.The WSOP notes, however, that this humble self-deprecation “belied his long experience in the game, which he’s played since the ’90s, and his learning sessions via playing many of Chicago’s best mixed-games pros.” Of course, despite now being a poker champion, Albini is best known for his influential contributions to the music world. Steve Albini has, by his own estimation, worked on several thousand albums over the course of his career. He’s the founder, owner, and principal engineer at Chicago’s Electrical Audio, and is well-known for his decorated resume—including Nirvana‘s final album, 1993’s In Utero—as well as his unusual approach to the producer role, both in philosophy and in practice. In addition to simplifying the process and handing the band the reigns (“If a record takes more than a week to make, somebody’s fucking up”), he also declined to take regular producer royalties on moral grounds. As he famously wrote to the members of Nirvana after In Utero‘s release: “I do not want and will not take a royalty on any record I record. I think paying a royalty to a producer or engineer is ethically indefensible. The band write the songs. The band play the music. It’s the band’s fans who buy the records. The band is responsible for whether it’s a great record or a horrible record. Royalties belong to the band. I would like to be paid like a plumber. I do the job and you pay me what it’s worth.”Congratulations to [World Series of Poker gold bracelet winner] Steve Albini![H/T Pitchfork]last_img read more

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Treatment resistance in some cancer cells may be reversible

first_imgThe ability of cancer cells to resist treatment with either targeted drug therapies or traditional chemotherapy may, in some cases, result from a transient state of reversible drug “tolerance.”  In a paper that will appear in the journal Cell and is being released early online, Harvard researchers at the Massachusetts General Hospital (MGH) Cancer Center report finding small populations of drug-tolerant cells from several different types of tumors and identifying aspects of the underlying mechanism.“While resistance to cancer drugs can result from rare, pre-existing genetic mutations that emerge in response to treatment, accumulating evidence has pointed to additional nongenetic, potentially reversible mechanisms,” says Jeffrey Settleman, PhD, of Harvard’s graduate program in Biological and Biomedical Sciences and the MGH Cancer Center, who led the study.“In cell lines derived from several different types of cancer we found subpopulations of cells that display a transient ability to tolerate exposure to toxic drugs, which was associated with structural changes in the cells’ DNA and points to a therapeutic strategy that could potentially prevent resistance from developing,” said Settleman, the Laurel Schwartz Professor of Medicine at Harvard Medical School.When cells within a tumor that had responded to treatment resume uncontrolled growth, drug therapy is usually stopped.  But there have been many reports indicating that some tumors can regain sensitivity to the previously ineffective treatment after a “drug holiday.”  In order to investigate the mechanism underlying that phenomenon, the researchers tested several tumor-derived cell lines against drugs to which the original tumors were known to be sensitive.In each of the lines they examined, a small number of tumor cells survived exposure to concentrations of drug 100 times greater than levels that killed the vast majority of the cells.  But when these drug-tolerant cells were placed in an environment without the drug, their offspring eventually regained sensitivity to the drug.Further investigation revealed that drug tolerance was associated with changes in gene expression, implicating alterations in chromatin, the chromosome structure consisting of DNA wrapped around a protein scaffolding. The researchers found that a particular chromatin-modifying enzyme was required for the development of tolerance, and while no currently available drug inhibits that protein, agents that block an associated group of enzymes did cause the death of drug-tolerant but not drug-sensitive cells.“We believe this kind of reversible drug resistance may be a fundamental property of many tumor cell populations,” says Settleman.  “Determining whether what we see in cell cultures will translate into what happens in patients is essential, and we’ve already started a clinical trial to see if combining a chromatin-modifying agent with the targeted lung-cancer drug erlotinib [Tarceva] may prevent or delay the development of resistance.  We’re also using our cell culture models to further explore the underlying mechanisms.”Sreenath Sharma, PhD, of the MGH Cancer Center is lead author of the Cell paper and Marie Classon, PhD, is co-corresponding author. Additional co-authors are Diana Lee, Bihua Li, Margaret Quinlan, Fumiyuki Takahashi, Shyamala Maheswaran, PhD, Ultan McDermott, Nancy Azizian, Lee Zou, PhD, Michael Fischbach, PhD, Ben Wittner, PhD, and Sridhar Ramaswamy, MD, MGH Cancer Center; and Kwok-Kin Wong, MD, and Kathleyn Brandstetter, Dana-Farber Cancer Institute.  The work was supported by grants from the LUNGevity Foundation, Goldman Philanthropic Partnerships, and the National Institutes of Health.last_img read more

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