Chemistry Nobel Celebrates Cell Complexity

first_imgA discovery rivalling the elucidation of the genetic code is the structure of the ribosome – the “molecular machine” that translates the DNA code into proteins.  Untangling the complexity of this multi-part system won three scientists the Nobel Prize for Chemistry (see BBC News).  The winners are Venkatraman Ramakrishnan, Thomas Steitz and Ada Yonath.    Science Daily included a photo model of the ribosome and described its action:Inside every cell in all organisms, there are DNA molecules.  They contain the blueprints for how a human being, a plant or a bacterium, looks and functions.  But the DNA molecule is passive.  If there was nothing else, there would be no life.    The blueprints become transformed into living matter through the work of ribosomes.  Based upon the information in DNA, ribosomes make proteins: oxygen-transporting haemoglobin, antibodies of the immune system, hormones such as insulin, the collagen of the skin, or enzymes that break down sugar.  There are tens of thousands of proteins in the body and they all have different forms and functions.  They build and control life at the chemical level.    An understanding of the ribosome’s innermost workings is important for a scientific understanding of life.Some factoids gleaned from the reports: the ribosome contains “hundreds of thousands of atoms.”  New Scientist said that the ribosome includes a “fact-checker” which “explains why nature produces so few faulty proteins.”  Ramakrishnan said, “we knew this was a large molecular machine that translated genetic code to make proteins, but we didn’t know how it worked.”  It took many years of X-ray crystallography and other delicate techniques to determine the structure.  “We still don’t know exactly how it works, but we have made a tremendous amount of progress as a direct result of knowing what it looks like,” he added.    PhysOrg, echoing an AP story, brought Darwin into the picture – albeit briefly.  “Their work builds on Charles Darwin’s theory of evolution and, more directly, on the work done by James Watson, Francis Crick and Maurice Wilkins, who won the 1962 Nobel Prize in medicine for mapping DNA’s double helix, the citation said.”  The article did not elaborate on the Darwin connection.  It appears to be a missing link.    PhysOrg also reported on an important link in the chain from code to protein that is coming to light: how the transcription process begins.  It’s another complex process still being explored.  Scientists in Munich have found one more step in the initiation process.  Patrick Cramer had this to say: “The findings led us to propose a model of the whole complicated process of transcription initiation, an operation that is of crucial importance in all organisms, because it determines which genes are expressed, and when.”  The process from gene to protein “must be carried out with great precision” and involves “the use of complicated assemblies made up of many different proteins, often referred to as molecular machines.”    Speaking of gene expression, an article last month on Science Daily revealed an even higher level of complexity: “protein regulators are themselves regulated.”  Helge Grosshans (Friedrich Miescher Institute) explained what he found: “What was formerly conceived of as a direct, straightforward pathway is gradually turning out to be a dense network of regulatory mechanisms: genes are not simply translated into proteins via mRNA.  MicroRNAs control the translation of mRNAs into proteins, and proteins in turn regulate the microRNAs at various levels.”Throwing Darwin’s name into this story was like tossing a fly into perfume.  Get it out as fast as you can.  Darwin had nothing to do with this; to him, a cell was a nearly featureless blob of protoplasm.  No way could he have envisioned any of this complex machinery.  If he had known about it, he might have become a creationist.    While these scientists are certainly deserving of recognition, the one to praise is the Creator of these amazing systems of information-guided machines.  They are just the latest in a long sequence of scientists who have gradually lifted the veil on the factory only to marvel at what they found.  For a stimulating read, pick up a copy of Stephen Meyer’s Signature in the Cell (see 06/27/2009 Resource of the Week).  You’ll not only learn the fascinating story of how these systems were discovered and how they work; you’ll be convinced forever that modern biochemistry leaves Darwinism defunct in the wastebin of discredited myths.  No attempt to resurrect Charlie’s corpse can succeed with what we have learned.  Let the dead bury their dead.  Follow the living Lord.(Visited 9 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

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Bafana down Mozambique in Nelspruit

first_img12 September 2012Gordon Igesund oversaw his first victory as Bafana Bafana coach at Mbombela Stadium in Nelspruit on Tuesday evening as the South African national team defeated Mozambique 2-0 in a friendly international.Two goals, one early and one late, by Kaizer Chiefs marksman Bernard Parker sealed the win in front of a small crowd.The victory continued South Africa’s excellent record at the venue. They’ve played there five times, won all five matches, and not conceded a single goal.There were three changes to the team that went down 1-0 to Brazil. Moneeb Josephs was given the nod in goal ahead of Itumeleng Khune, who had excelled in Sao Paolo. Parker took over from Dino Ndlovu and substitute Benni McCarthy up front, and Reneilwe Letsholonyane replaced Kasgisho Dicgacoi, who had returned to Crystal Palace.Confident startBafana Bafana played confidently from the start of the game, enjoying the lion’s share of possession and controlling the play against a Mambas’ line-up that was missing some of the players that had helped them to an impressive 2-0 win over Morocco on Sunday.Despite this, the South African side didn’t find Mozambique’s defence easy to break down after hitting the front in the seventh minute.The goal came when midfielder Siphiwe Tshabalala set up Parker with a well-played through ball and the striker provided the necessary finish with a left-footed shot across the goalkeeper Nelson Logomale to put the home side in front.Letsholonyane was a little high with a half-volley and defender Bongani Khumalo was just wide with a header before Parker came close to notching a second goal after 25 minutes, but his shot passed narrowly over the bar.The Mambas’ Helder Pelembe then sounded a warning with a powerful shot that passed just over the crossbar of the South African goal.DisallowedJust before the break, Tshabalala picked out Khumalo from a free kick and the defender found the back of the net. The linesman, however, disallowed the goal. Replays revealed he had got his decision wrong.Both teams made changes at the break, which had a noticeable effect on the second half of the contest, with the match losing some of its shape.After an hour, Parker got onto the end of a Tshabalala cross, but Logomale was up to the task and stopped the shot. Parker then played Tshabalala in, but Logomale again denied the South African attack.Clesio Baugue fired narrowly wide for Mozambique and Tshabalala was just off target with a curling shot before Parker sealed the victory in the 87th minute.GoalAfter a nice, flowing move, substitute Thamsanqa Gabuza provided a cross from the right for Siboniso Gaxa, who cleverly left the ball, allowing it run for Parker. The striker made no mistake with his shot to double South Africa’s advantage.Josephs nearly gifted the visitors a goal with time almost up when a heavy touch on the ball led to Baugue stealing possession away from the goalkeeper. Defender Bevan Fransman, however, reacted quickly and cleared Baugue’s goalbound shot off the line.Bafana Bafana will play their next match in exactly a month’s time when they take on Poland in Bydgoszcz on 12 October.Would you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more

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Budget 2016: Tough balancing act in a tough global environment

first_imgSouth Africa’s 2016 National Budget was tabled in challenging global economic conditions, with low growth at home, Finance Minister Pravin Gordhan said at a media briefing on Thursday.“It’s a tough Budget,’ he said. “We are finding ourselves in a very difficult global economic environment with lots of doubt on whether the developed world will continue to grow . We’ve seen that currencies of emerging markets have been affected and commodity producers have been affected.’The Budget, tabled in Parliament on Wednesday, comes at a time when high unemployment levels and slow growth have demanded greater investment by the government.“We have our own internal difficulties as South Africa,’ Gordhan said. “We’ve been growing too slowly. Our unemployment levels are too high, poverty and inequality levels are also high … Government has, for the last six years or so, been carrying the substantial burden of investing in infrastructure, for example.’He said the country must come up with new answers.“At the same time, we’ve borrowed a lot since 2009 in order to sustain, in particular, our social services and invest in infrastructure and the economy more generally. We haven’t grown at the same level as we borrowed.’This, he said, means South Africa must rein in spending.“This means we have to tighten our belts, tax a little bit more without hurting the economy and cut expenditure within government as well. That’s the balancing act temporarily. I hope that we have to perform it until all of us can put our heads together and say: How do we grow this economy? How do we get more investment? How do we create more jobs?’Tax relief and tackling debtThe 2016 Budget makes tax proposals that include a personal income tax relief of R5.5-billion, partially compensating for inflation, focused on lower- and middle-income earners.Gordhan pointed out that South Africans’ household debt is high.“Indebtedness in South Africa is a serious problem,’ he said. “Unsecured lending, at one stage, was a serious problem. The message is, we will try to do whatever we can, as we have done this time. Where there are possibilities of tax relief, we will direct the tax relief at the lower end. For example, to mitigate inflation, the money that we’ve put in (R 5.5-billion) is going to the lower income brackets.’He urged South Africans not to overextend themselves financially. “Like government, everybody needs to balance their budgets as well until we can get the economy to start growing.’On the nuclear build programme, Gordhan said the Budget stance is that nuclear will be expanded at a scale and pace that is affordable following a thorough and transparent tender process.“We are at the very early stages of the programme. We will phase in the implementation of a programme like that in accordance with our affordability. We have to go through a proper, transparent procurement process.’Investment and structural reformGordhan also spoke of the need for investment to grow the economy.“For the purposes of growth, we require more investment both from government and from the private sector. We need more creative energy from our own people, we need entrepreneurs on a large scale and support for small, medium and micro-sized enterprises.’In his Budget speech on Wednesday, Gordhan emphasised that structural reforms – such as those detailed in the National Development Plan – were needed to “turn the South African economy’s direction towards hope’.“The Budget tabled today is guided by the NDP,’ he told Parliament. “It is a Budget for inclusive growth, it emphasises partnerships among role players in our economy, it prioritises education and infrastructure investment, it supports employment creation and it contributes to building a capable, developmental state.’Source: South African Government News Agency and South Africa.info reporterlast_img read more

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Nine Surprising Signs That Momentum Is Building for Climate Action

first_imgOther nations are making notable stridesWhile China is a pace setter, it is not alone. All told, global green energy investment jumped nearly 17 percent in 2014 from the previous year, topping an unprecedented $270 billion according to a UN-backed report.Examples of this investment abound. Oil-rich Dubai just announced a $3 billion solar project expansion. Mexico made a larger-than-anticipated pledge in 2014, to cap its carbon emissions by 2026 and to achieve a 22 percent reduction in global warming emissions by 2030. And other nations continue to break new ground in the race for a low-carbon future. In March, for instance, Costa Rica announced that its state-run electricity company had powered the country exclusively with renewable resources (including hydropower) for a record-breaking 75 consecutive days.Our world is still powered predominantly by burning fossil fuels and the imminent threats posed by climate impacts continue to grow. But make no mistake: with a growing catalog of developments like these, a cleaner and greener future is seeming more achievable than ever before. Regional emissions reduction plans are exceeding expectationsA new report from the nine states participating in the Regional Greenhouse Gas Initiative (RGGI) highlights the continuing success of the nation’s longest-running carbon market, showing that it really is possible to tackle our climate and energy challenges while delivering huge benefits to consumers.According to the report, RGGI states have successfully cut emissions by 40 percent since 2005 while their economies have grown by 8 percent. Meanwhile, the $1.4 billion in proceeds from their auctions of emissions credits have been invested in energy efficiency projects that will return more than $2.9 billion in lifetime energy savings to millions of households and businesses. In the year to come, look for other states to wake up to these figures — either by asking to join RGGI or by forging regional carbon trading plans of their own. Red states among wind and solar leadersDespite a lot of partisan talk in Washington, renewables are ramping up in many unexpected places. Consider, for example that, aside from California, North Carolina installed more solar photovoltaic systems last year than any other state in the country, with enough solar installations now to meet the needs of close to 100,000 homes. And Texas — a state practically synonymous with fossil fuel production — installed more wind turbines than any other state in 2014. Employing forward-thinking policy and investment, Texas nearly doubled its wind energy generation between 2009 and 2014 to now generate nearly 10 percent of its electricity from wind power. Record-breaking coal retirementsIn a report issued last month, Bloomberg New Energy Finance forecast “the largest wave of coal retirements in U.S. history.” This is good news for air pollution and the carbon emissions that drive global warming.According to the Bloomberg report, fully 7 percent of U.S. coal energy generation is expected to shut down in 2015, spurred by the onset of a key mercury emissions rule and also by tougher economic competition from other energy sources. The upshot, according to this hard-nosed energy forecast: a “fundamental reduction in coal’s share of the U.S. power mix” and a significant step toward reducing the nation’s carbon footprint. RELATED ARTICLES Hoping for a Climate Change BreakthroughTaking Action on Climate ChangeEarth Day 2014 and Climate ChangeIn the West, Drought Ends ‘Era of the Lawn’Half of All Americans Worry About Climate ChangeGood News Bad News With Climate ChangeSeeking Common Ground on Climate Change PolicyThe Uncertain Future of Phoenix and Las VegasScience, Climate Change, and Policy The Science of Global Warming Is Older Than Quantum MechanicsThe Connection Between Obesity and Climate ChangeAvoiding the Global Warming Impact of Insulation China is beating its own ambitious pledgeIn an agreement with the United States at the end of last year, China pledged to cap its carbon emissions by 2030 and increase its share of non-fossil fuels to around 20 percent in the same time period. While China has yet to publish the details of its plan, it appears to be moving even faster than its pledge would require.According to the latest figures, China burned less coal in 2014 than it did the previous year, the first such decline in decades. At the same time, as my colleague Michael Klare has noted, China increased its spending on renewable energy by an impressive 33 percent in 2014, investing a total of $83.3 billion. That’s the most a country has ever spent on renewables in a single year. The Pope is getting involvedPope Francis is laying the foundation for a substantive campaign to combat global warming and environmental degradation, with an imminent Vatican summit meeting and plans for a potentially influential encyclical on the subject this summer.The development shouldn’t be underestimated as a catalyst for change. As Timothy E. Wirth, vice chairman of the United Nations Foundation recently told The New York Times: “We’ve never seen a pope do anything like this. No single individual has a much global sway as he does. What he is doing will resonate in the government of any country that has a leading Catholic constituency.” In particular, the Pope’s exhortations on the subject are expected to speed climate action in some Latin American countries that have resisted getting involved up to now. Tea Party loyalists are revolting to back solar solutionsMuch to the chagrin of the Koch brothers who helped launch the Tea Party in 2009, a growing number of Tea Party activists are turning on their pro-fossil fuel backers to support solar energy. Last year, Debbie Dooley, one of the Tea Party’s original founding members, went head-to-head with the Koch-backed branch of the Tea Party to successfully persuade Georgia’s utility commission to require Georgia Power to buy more of its energy from solar sources.Now, in Florida, some 85 Tea Party groups are joining a broad bipartisan coalition called Floridians for Solar Choice to support a popular ballot initiative that would amend the state’s constitution to allow individuals and businesses with solar panels to sell the power they generate directly to their tenants or neighbors. California breaks new ground on renewablesLast week, Governor Jerry Brown set aggressive new global warming emissions targets for California that put the nation and the world on notice. His plan calls for California to reduce emissions 40 percent below 1990 levels by 2030. That’s a timetable for steep emissions reductions almost unthinkable just a few years ago. And considering that California is the world’s eighth largest economy, the state’s actions make a big difference. Seismic shift in global business communityIn a notable development, the G20 powers recently launched a joint probe into the global financial risks posed by the potential for fossil fuel companies’ so-called “stranded assets” — investments in costly ventures that may never be viable in light of emerging international climate agreements.G20 nations have asked for an independent assessment of whether fossil fuel companies’ $6 trillion of investment into oil, gas, and coal development since 2007 might be based on false assumptions about demand that could risk the bursting of a so-called “carbon bubble.” Equally notable in the new zeitgeist, Newsweek recently reported that HSBC — the world’s third largest bank — wrote a private note to its clients advising them to divest from fossil fuel companies because of increasing risks they will become “economically non-viable.” Considering that five of the top six Fortune 100 companies are still in the oil refining business, if that doesn’t mark a sea change in thinking, I don’t know what does. A spate of recent developments suggests momentum is building to address climate change — including some truly unexpected and inspiring signs in the United States and around the world.Of course, huge obstacles remain: Florida Governor Rick Scott would allegedly like to censor any official mention of the subject. Oklahoma Senator Jim Inhofe still seems to think that carrying a snowball onto the floor of the Senate offers some kind of “evidence” that global warming is hoax.And more worrisome, fossil fuel interests including the Koch brothers and Shell Oil are still spending millions trying to repeal renewable energy standards in states around the country through the work of the American Legislative Exchange Council (ALEC) and other front groups. But consider the following and see if you don’t agree that, when it comes to climate change, dramatic changes are afoot. Equally impressive, virtually all the evidence shows that California has profited mightily from its green energy economy so far, attracting an estimated $27 billion of venture capital into California clean tech companies since 2006. Seth Shulman is the editorial director at the Union of Concerned Scientists and a veteran science journalist whose work has appeared in Nature, The Atlantic, Discover, Technology Review, Parade and many other publications. This post originally appeared at The Huffington Post. Peter Dykstra wrote about this subject last month.last_img read more

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TNT solves SMB puzzle

first_imgOil plant explodes in Pampanga town Christian Standhardinger paced the Beermen with 24, and Von Pessumal had a 23-point night that came to naught as San Miguel got untracked in the second half with just 42 points, 17 in the final frame.TNT thus climbed into a 2-2 tie with its victim and Columbian, which took a 107-97 loss at the hands of NLEX in the first game.The Road Warriors opened up an 18-point lead in the first six minutes, bloated it to 31 late in the second quarter, and sat on a 24-point bubble at the half which proved too big for the game Dyip to overhaul in the last two periods.It was the first win in three games for coach Yeng Guiao, who sat on pins and needles in the final two frames after the Dyip came perilously close early in the fourth period only to lose steam and be at a level 2-2.“It’s hard to put that team away, they just come at you every time,” Guiao said after drawing twin digits in scoring from five players led by the 23 of new acquisition Poy Erram.ADVERTISEMENT SEA Games hosting troubles anger Duterte LATEST STORIES Sports Related Videospowered by AdSparcRead Next Lacson backs proposal to elect president and vice president in tandem US judge bars Trump’s health insurance rule for immigrants “They (Dyip) are relentless and they are going to be a force [in this tournament].”The Road Warriors gave up a lot to get their hands on the 6-foot-7 Erram, who also had 10 rebounds, six assists and five blocks in just under 36 minutes as he finished off his outing with eight points in the fourth period.“We’re very happy with the way Poy is coming up,” Guiao said. “He’s starting to settle down.”Another  revelation for Guiao is Marion Magat.  The lanky center tabbed from the free agent market had 14 points and 13 rebounds in 26 minutes off the bench. Private companies step in to help SEA Games hosting Oil plant explodes in Pampanga town View comments PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Eala jumpstarts new season with two int’l runner-up stints Grace Poe files bill to protect govt teachers from malicious accusations ‘We are too hospitable,’ says Sotto amid SEA Games woes Don’t miss out on the latest news and information. Jayson Castro can’t remember the last time TNT KaTropa beat San Miguel Beer.After hitting all nine of his two-point attempts and finishing with 24 points and 11 assists, Castro helped the KaTropa snap a 10-game losing streak to the Beermen—dating nearly two years—as TNT won a second straight PBA Philippine Cup match, 104-93, at Smart Araneta Coliseum in Cubao on Sunday night.ADVERTISEMENT MOST READ “I really can’t remember, because it’s been all losses,” Castro said in Filipino when someone asked him if he remembered their last win over San Miguel.“That’s why this [win] is special, because it gives us confidence that we can handle the [four-time] defending champions.”FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsTNT’s last triumph over San Miguel came in Game 4 of the Commissioner’s Cup Finals on June 2017, and for most of Sunday night, the Beermen appeared ready to extend that streak only for Castro and Troy Rosario to rescue the KaTropa.Castro also finished with 11 assists and Rosario wound up with 23 points built around a 6-for-12 clip from three-point range.last_img read more

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Colombo Test: Mendis, Karunaratne show grit as Sri Lanka live to fight another day vs India

first_imgKusal Mendis hit a fighting century and shared 191 runs with opener Dimuth Karunaratne as Sri Lanka battled to escape innings defeat against India in the second cricket Test on Saturday.Sri Lanka was forced to follow on with a 439-run first innings deficit after India bowled them out for 183 in its first innings. However they ended the third day well on 209 for two but still needing 230 runs to make India bat again.Mendis was out for 110, his third Test hundred a few overs before close of play caught by wicketkeeper Wriddhiman Saha off seamer Hardik Pandya. He faced 135 deliveries and hit 17 boundaries.Karunaratne was unbeaten on 92 batting with night watchman Malinda Pushpakumara on two. Karunaratne faced 200 deliveries and hit 12 boundaries in his watchful innings.India declared its first innings on 622 for nine.India reaped early success when fast bowler Umesh Yadav bowled out opener Upul Tharanga (2) with a ball nipping back into the left-hander with the team on seven runs.However both Mendis and Karunaratne made Indian bowlers to toil specially Mendia scoring bulk of his runs with the sweep shot.Niroshan Dickwella who scored Sri Lanka’s only half-century in the first Test said his team came out with a different mindset in the second innings after a long meeting at lunch interval.He said they had plans to use more of the sweep and reverse sweep shots as scoring options.Ravichandran Ashwin, who bagged his 26th five-wicket haul in the first innings, went wicketless having bowled 24 overs.Ashwin said that Indian bowlers were not faulty in the second innings but credited Sri Lanka’s batsmen for good batting.advertisement”We beat the bat pretty often even in the sessions we didn’t get the wickets. I thought they batted really well.””I don’t think we did too much wrong, we tried all, reverse swing, we bowled cutters. It (the pitch) is slowing down at a very very quick pace, the edges are not carrying. That means we have to stick our guns out and get a few wickets.”The hosts resumed the third day on 50 for two in their first innings but lost their remaining eight wickets for 133.Ashwin finished with five for 69 while fellow spinner Ravindra Jadeja and fast bowler Mohammed Shami took two wickets each.Jadeja broke through first in the day having Dinesh Chandimal (10) caught by Pandya. Chandimal’s overnight partner Mendis attempted to force Yadav over the infield only to be caught by Indian skipper Virat Kohli.Ashwin forced Angelo Mathews (26) for a close-in catch to Chetenshwar Pujara and Jadeja bowled out Dhananjaya de Silva.Dickwella played an aggressive innings in a bid to break free from pressure. But Shami bowled him out for a 48-ball 51.A win here will seal the three-match series for India after their 304-run win in the first Test.last_img read more

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How Inbound Marketing Aligns With the New Purchase Loop

first_imgIn 1898, Elias St. Elmo Lewis developed the Purchase Funnel, the now familiar pathway customers travel from consideration to purchase. There are four steps in the process that have always been integral to every CMO’s approach to marketing: Awareness, Interest, Desire, Action. conducted by Latitude found Awareness Desire Inbound Marketing – At this stage, the consumer moves from initial interest to a research mentality to gain an understanding of the broad fundamentals in order to make a purchase the consumer can feel good about. on which they would find a whitepaper on, say, marketing automation – This step is an exponential progression from the Interest stage. The person moves from a “nice to have” mentality to a “must have” mentality. – A person becomes aware of the product either through advertising or the recommendation of a friend. the internet was integral to the process for three quarters of respondents. With that finding, one has to call into question the millions of dollars brands spend to “build awareness” when, clearly, every other medium is more heavily relied upon. Akin to the second step in the loop, this third step sees our vacationer understanding there are certain home safety-related steps they must take before they leave town. They know they need to inform their neighbors; they know they need to make sure their home alarm system is in working order; they know they need to arm themselves with home safety-related information — so after having downloaded and read your whitepaper, they would be receptive to the follow-up Image credits: The Role of Inbound Marketing – A piece of information, a news story, an article, or a friend’s recommendation acts as a catalyst, giving the consumer a reason to start looking into things the person wants or needs. – Following purchase, the consumer uses and experiences the purchase to decide how he or she feels. At this stage, they might post a product review or share their experience with friends. Topics: – The person puts desire into action and makes a purchase decision. The study identified six behavioral or mental states a buyer experiences when considering a purchase. effective SEO strategies Realized Want or Need inbound marketing 1) Openness ), but if they read an article about how the best way to hide things is in plain sight (or in places no one would ever think to look), they might become more open to the idea of considering such a product. 5) Research and Vetting linear — that a person can bounce from one stage to another as they make their way to final purchase. 4) Seeking Ideas and Inspiration This new purchase consideration track takes into consideration a person’s emotions, and understands the process How do you think the new purchase loop changes the way marketers do their jobs? program in place that generated SEO-friendly content which allows you to present a need, and also conveniently slip in a mention of your cheap but very effective solution. Here the vacationer realizes they will, in fact, be buying certain home safety products before they leave for vacation. Because you have determined their predilection for home safety products through the previous information they requested, you can offer them So, how does a marketer realign their tactics to better align with this new purchase consideration cycle? Put simply, your brand needs to be there when someone comes looking for a solution to the problem or need you serve. Let’s address what you as a CMO must have in place in each of the six stages when potential customers start looking. come into play. The person probably hasn’t come to the conclusion they need an electric socket that doubles and a place to hide valuables, but they do have general home safety concerns and don’t want their valuables at risk if their house is broken into while away. So they will be seeking broader home safety advice, and you want to be there via the right keywords, with a link to a product information page, blog post or Reliance on television, without surprise, has practically fallen off the map in terms of being a useful medium during the consideration process. 6) Post-Purchase Evaluation and Expansion email you would send them Openness The Purchase Funnel Learning and Education At this stage, a potential customer might not even know they need your product or service. But they are open to suggestions if they can be convinced there is a need. For example, a person may not know they need an electric socket that’s actually a security drawer to hide valuable items (yes, a product like that exists 2) Realized Want or Need – Here the consumers gathers information to support feelings of purchase intent. Options are compared, deals are sought, prices are compared, and reviews are read all to determine personal associations with the brand. Post-Purchase Evaluation and Expansion The 6 Behavioral and Mental States Involved in the New Purchase Loop 87% of consumers now travel a less linear, more complex pathway to final purchase. Because they bought from you and because they are in your Seeking Ideas and Inspiration progressive profiling on your landing pages Action – After having been made aware of the product or service and determining its relevance, the person expresses interest. Interest customized, relevant information – Here, the consumer seeks a solid reason to look for, notice, and keep track of examples, thought-starters, and motivators surrounding the product in question in order to take the next step. Here, because our vacationer seeks a solid reason to look for, notice, and keep track of examples, thought-starters, and motivators surrounding the idea of home safety, additional content assets would be helpful. Think things like case studies or testimonials from customers who had the misfortune of having their house broken into but, because they had your nifty electric socket hideaway, didn’t lose any of their valuables. And you would be able to send better targeted content assets, because you used The Top Ten Home Safety Concerns When Going on Vacation. How would they come to this conclusion? By reading a piece of content that addressed home safety — like a blog post with the five steps one should take before they leave for a month-long vacation. And how would they find this information? They’d find it from you, because as CMO, you would have an to deliver them information on the additional home safety products you offer, such as the in-wall oven that’s actually a heavy duty safe. Okay, that’s not actually a real product. At least not to my knowledge. recent study It’s extremely important to note that these six stages do not always occur in linear order. Rather, they align with the differing and not always logical state of human emotions that come into play during a purchase decision. But with proper inbound marketing tactics applied to each of the six stages, you’ll be well positioned to address the needs of your target audience, convert them into leads and, ultimately, into customers to drill down into what the vacationer’s more specific pain points were. lead management system In each of the six stages, the internet far outweighed all other media used during the purchase consideration process. In every stage except post-purchase, such as a report on the cost benefit analysis of various home safety products. Your product being the best choice for their needs — needs which you’ve gotten to know over the course of your interactions with them — leads to a purchase of your product. landing page isn’t Just 29% report relying on the medium even at the earliest stage. Research and Vetting Originally published Feb 8, 2013 2:00:00 PM, updated October 20 2016 – Consumers experience a receptiveness to new or better experiences, which results from pre-existing interest in or curiosity about a category or topic area. At this stage, it can be a conscious or unconscious desire for a brand. The study also took a look at the types of media used during each stage of the process. At this point, the person heading off on that month long vacation to Belize may have come to the realization that there are home safety concerns with which to contend. So they run off to Google and type in “home safety.” This is where While this purchase funnel has served marketers well over the years, a (since you collected their email address on the landing page) which offered another whitepaper or report that further explained the importance of home safety, and the steps they could take to achieve it. About.com Latitude Study , you can continue to market to them using 3) Learning and Education Don’t forget to share this post! AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to Email AppEmail AppShare to LinkedInLinkedInShare to MessengerMessengerShare to SlackSlacklast_img read more

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16 Brands That Totally Nailed Their Homepage Designs

first_img Originally published Aug 23, 2013 8:00:00 AM, updated November 29 2017 Website Design Examples Homepages are the online version of a handshake at a networking event. At an event, you’ve gathered up the courage to approach someone else there to strike up casual conversion, and you’ve got one shot to make a great first impression: the handshake.But there’s actually a lot more to the handshake than you might think. You have to be firm yet unaggressive, all while making eye contact, introducing yourself, and trying to remember the other person’s name (in addition to hoping your hands aren’t as clammy as they feel).Learn the fundamentals of inbound marketing in a short online lesson from HubSpot Academy. When it comes to your homepage, someone else has most likely been searching online and stumbled on your website. So your homepage has to be compelling enough to make them want to stay and interact with you (just like the handshake). This subsequent interaction may include exploring your “about us” page, or even converting into a lead via a call-to-action (CTA). Even though it seems simple — your homepage is just one page after all — making a solid first impression is key, and it’s not easy. So how do you make sure your website has a great handshake? Although there is no one true formula for a solid homepage, you can start to see patterns in examples of really awesome ones. To help you see what I mean, here are 16 awesome homepage designs you can’t help but fall in love with:1) Rezdy Rezdy’s use of visual elements such as icons and arrows allow the company to clearly explain the purpose of its product without having to rely on heavy copy.2) Jay Z’s Life+TimesIf anyone knows how to entertain, it’s Jay Z. The eclectic nature of his personal website mirrors his real-life brand in this interactive tile-based homepage.3) Sagmeister & Walsh This page offers a truly unique way to address site navigation. Called augmented reality, each element on the floor can be clicked to advance the reader through the site, a visual that definitely sets it apart.4) CollaborateThe layout of this website effectively handles several different user stories by presenting three different CTAs without them compete against one another. 5) Prezi  This page sets up a clear information hierarchy and thought sequence. Everything that you need to know is provided in a few pixels via a video, company tagline, and clear CTA. The video is also a smart addition if Prezi’s target audience wants more in-depth information.6) Fanabee This website uses parallax scrolling to deliver a unique user experience. Reaching out to “mega fans” on the banner also subtly conveys exclusivity, compelling the audience to click its CTA and see what’s behind the velvet rope. 7) UrbanBoundPutting the CTA front and center, as UrbanBound does here, is another great example of a web design that focuses its most important information in the center of the page. 8) JIB A great use of a simple illustration, excellent complementary color palate, crystal clear copy, and a single call-to-action all combine to make this website’s homepage one of our favorites.9) Galpin The Galpin page uses typography to showcase its character. Notice that the page focuses less on graphics, and instead uses text to convey its messaging. 10) Surf RightEasy navigation and beautiful design can (and should) work together. An interactive slider and a well-organized set of tiles make this website easy to surf … hehe, get it? ;)11) Riley Cran Here we see another appealing tile-based website design. Setting Riley Cran apart is the fact that the entire site is set within a single page — no scrolling necessary!12) New BreedNew Breed’s website effectively balances its different buckets of content and presents it all in a well-organized, easily-digestible page.13) SilkTricky Another example of content organized into visual tiles is SilkTricky. Notice the use of a carrot visual element (the white triangle in the text boxes) to unobtrusively connect the site’s text and visuals for the reader.14) Function PointFunction Point’s website maintains a consistent look and feel across all of its design elements. The site’s illustration, style, and choice of colors also help enhance the design and build a visual hierarchy.15) WoodworkDespite the potentially overwhelming visuals on this page, clear navigation and layout (shown here) ensures that the user isn’t overwhelmed. 16) Quarter Rest StudiosThis homepage is essentially one large slideshow paired with a simple top navigation. It gives the visitor a limited but useful set of options — presumably ideal for the magazine’s visual-based target market. Don’t forget to share this post! AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to Email AppEmail AppShare to LinkedInLinkedInShare to MessengerMessengerShare to SlackSlackcenter_img Topics: Which homepage is your favorite? For more homepage designs to inspire you, download our free collection of 53 homepages here!last_img read more

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